Hemochromatosis occurs most often in people of northern European ancestry, especially those of Scottish, Irish or English descent, and affects up to 1 in 200 people in the United States. Hemochromatosis most commonly is diagnosed in people between ages 40 and 60. In women, it usually is diagnosed after menopause.
Is haemochromatosis hereditary?
There is a lot to look forward to.” Haemochromatosis is a genetic iron overload disorder. It is particularly prevalent among Irish and other Celtic people. The condition causes people to absorb excessive amounts of dietary iron which, over time, may lead to serious organ damage.
Do Irish people suffer from hemochromatosis?
Now that we have iron-heavy foods readily accessible, the evolutionary development has become a disease that disproportionately afflicts people with Irish, Scottish, Welsh, and British heritage, who are three times more likely to suffer from hemochromatosis.
Is there genetic testing for hemochromatosis?
However, there is no general agreement that this approach is useful. Genetic testing is available for two of the more common genes associated with this disorder (found in up to 90% of people with hemochromatosis), but not everyone who has the genes develops the disease.
What causes hemochromatosis in Ireland?
Because it is caused by a recessive gene, hemochromatosis will only occur if both parents pass on the mutated gene. People with only one mutated gene are carriers. Among the Irish, estimates suggest that one in four are carriers.
How true it is that hemochromatosis is genetic?
Partly true: The disorder is called hereditary hemochromatosis and it is an autosomal recessive disorder . Meaning it is passed from parent to offspring, people can be carriers of the gene, and you have to have 2 copies of the gene to have the disorder: one from the father and one from the mother.
What is the prognosis for hemochromatosis?
Prognosis of hemochromatosis. The degree of organ damage, especially in the liver, is decisive for a prognosis. Patients with severe liver tissue scarring (cirrhosis) and diabetes appear to have a shorter life expectancy. Otherwise life expectancy is normal.
Is hemochromatosis a dominant or recessive trait?
Hereditary Hemochromatosis is inherited in an autosomal recessive or autosomal dominant manner, depending on which type a person has. Hemochromatosis types 1, 2, and 3 are inherited in an autosomal recessive manner. T
Can hemochromatosis be cured?
No, haemochromatosis is a genetic condition and cannot be cured. It can be successfully managed by venesection (blood removal) to reduce the level of iron in your body or chelation therapies, which allow excess iron to be excreted through the urine.