What causes neutropenia in cancer patients

Neutrophils are produced in the bone marrow at the center of larger bones. Anything that disrupts this process can cause neutropenia. Most commonly, neutropenia is caused by chemotherapy for cancer. In fact, around half of cancer patients undergoing chemotherapy will experience some level of neutropenia.

What are the causes of neutropenia?

Neutropenia can be caused by: Infections, including hepatitis, tuberculosis, sepsis, or Lyme disease. Medications, including chemotherapy. Chemotherapy is one of the most common causes of neutropenia. Cancer and other blood and/or bone marrow disorders.

Can chemotherapy cause neutropenia?

Cancer chemotherapy is a common cause of neutropenia. In addition to killing cancer cells, chemotherapy can also destroy neutrophils and other healthy cells.

How does neutropenia affect children with cancer?

The activities of families of children with cancer can sometimes revolve around a patient’s ANC or “counts.” If counts are low, patients may receive medicine called growth factors. These drugs are given to increase the number of white blood cells. When patients have neutropenia, they may have to avoid public places such as schools.

What medications cause neutropenia?

In some people, neutropenia can be caused by certain medications, such as: Antibiotics. Blood pressure drugs. Psychiatric drugs. Epilepsy drugs.

Which infections may cause neutropenia?

Neutropenia may arise as a result of numerous medical conditions:

  • Infections (more commonly viral infections, but also bacterial or parasitic infections). Examples include: HIV,…
  • Medications that may damage the bone marrow or neutrophils, including cancer chemotherapy;
  • Vitamin deficiencies (megaloblastic anemia due to vitamin B12 or folate deficiency);
  • Radiation therapy;

What are the genetic causes of neutropenia?

What are the genetic causes of neutropenia? Syndrome Inheritance Gene Clinical Features Chediak-Higashi syndrome Autosomal recessive LYST Neutropenia, oculocutaneous albinism, gi Barth syndrome Sex linked TAZ Neutropenia, often cyclic; cardiomyopath Cohen syndrome Autosomal recessive COH1 Neutropenia, mental retardation, dysmorp 8 more rows Jan 17 2021

Which nutritional deficiencies cause neutropenia?

Nutritional deficiencies that can cause neutropenia include vitamin B-12, Folic Acid, and copper deficiency.

What are the most common neutropenia symptoms?

Signs and symptoms suggestive of neutropenia include: low-grade fever, skin abscesses, mouth sores, swollen gums, and symptoms suggestive of infections of the skin, perirectal area, mouth, or other areas of the body.