Mutations in the HBB gene cause sickle cell disease. Hemoglobin consists of four protein subunits, typically, two subunits called alpha-globin and two subunits called beta-globin. The HBB gene provides instructions for making beta-globin. Various versions of beta-globin result from different mutations in the HBB gene.
What are specific changes in the DNA cause sickle cell anemia?
Sickle cell anemia is caused by a change in the beta-globin gene, which is known as HBB. HBB codes for beta-globin, one of the building blocks of hemoglobin. The specific change in the gene that causes sickle cell anemia is known as the hemoglobin S, or Hb S, mutation.
Can genetic engineering cure sickle cell anemia?
Sickle Cell Cure Genetic Engineering Shows The Way. Sickle cell anemia is an inherited disorder that causes defective hemoglobin to be produced in the red blood cells. The defective hemoglobin leads to various clinical symptoms, and may reduce life expectancy. Presently, stem cell transplant from a healthy donor is the only hope for a cure.
How does sickle cell anemia affect life expectancy?
The life expectancy of people suffering from sickle cell anaemia is reduced. Some patients might survive for years, while others may not even survive infancy. Sickle cell anaemia is a genetic disorder. Both parents must be carriers of sickle cell anaemia for the child to be affected by this disease.
What race does sickle cell anemia affect?
The only race that tends to get a pass on sickle cell anemia are Caucasians of European descent. African-Americans tend to be a majority of the patients, up to 80% in some areas, but this disease affects those of Arab, Hispanic, Indian, and Mediterranean backgrounds as well.
What gene change causes sickle cell anemia?
What gene change causes sickle cell anemia? Sickle cell anemia is caused by a change in the beta-globin gene, which is known as HBB. HBB codes for beta-globin, one of the building blocks of hemoglobin. The specific change in the gene that causes sickle cell anemia is known as the hemoglobin S, or Hb S, mutation. What Causes Sickle Cell Disease?
What is sickle cell anemia and how does it affect you?
Sickle cell anemia is a genetic disease with severe symptoms, including pain and anemia. The disease is caused by a mutated version of the gene that helps make hemoglobin — a protein that carries oxygen in red blood cells. People with two copies of the sickle cell gene have the disease.
Can sickle cell anemia be passed on to children?
People who carry only one copy of the sickle cell gene do not have the disease, but may pass the gene on to their children. The mutations that cause sickle cell anemia have been extensively studied and demonstrate how the effects of mutations can be traced from the DNA level up to the level of the whole organism.
What chromosome is sickle cell anemia located in?
The gene that can cause Sickle Cell Anemia is called HBB and is located in Chromosome 11. HBB helps in the creation of hemoglobin in the body.